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Year : 2019  |  Volume : 3  |  Issue : 1  |  Page : 23-28

Skin in rheumatoid arthritis and seronegative arthritis

1 Department of Dermatology, Government Medical College, Nizamabad, Telangana, India
2 Department of Dermatology and Venereology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India

Correspondence Address:
Pragathi Sankineni
Department of Dermatology, Government Medical College, Nizamabad, Telangana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/CDR.CDR_47_18

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Rheumatoid arthritis is a multisystem inflammatory disorder affecting the joints, soft tissue, as well as extraarticular sites like the skin. Cutaneous manifestations occur in up to 40% cases and vary from specific to nonspecific lesions. Specific changes consist of rheumatoid nodules, neutrophilic dermatoses such as palisaded neutrophilic granulomatous dermatoses, rheumatoid neutrophilic dermatoses, pyoderma gangrenosum, and Sweet's syndrome; nonspecific changes include skin atrophy, wrinkling, palmar erythema, and Raynaud's phenomenon. Seronegative arthritis is a group of chronic inflammatory arthritis, which is typically negative for rheumatoid factor, and is often associated with HLA-B27. There is asymmetric peripheral polyarthritis with sacroiliitis and is often associated with cutaneous, ocular, genitourinary, and gastrointestinal abnormalities. Psoriatic arthritis, reactive arthritis, inflammatory bowel disease-associated arthritis, and ankylosing spondylitis are the major conditions seen in this group.

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